Canada : PhD Student Position in Biological Research ...

Heart has a limited potential to synthesize fatty acid (FA) and therefore FA is supplied from several sources: lipolysis of endogenous cardiac triglyceride (TG) stores, or from exogenous sources in the blood. Lipoprotein lipase (LPL), synthesized in cardiomyocytes, catalyzes the breakdown of the TG component of lipoproteins to provide FA to the heart. It is the vascular endothelial-bound LPL that determines the rate of plasma TG clearance and hence, it is also called heparin releasable (HR) "functional" LPL. Functional LPL is regulated by numerous dietary and hormonal factors, and is sensitive to pathophysiological alterations like those observed during diabetes. In this condition, absolute or relative lack of insulin impairs cardiac glucose transport and oxidation, resulting in FA becoming the preferred means of energy supply. To make available this increased requirement of the heart for FA, diabetic heart upregulates its luminal LPL activity by posttranslational mechanisms. Chronically elevated cardiac LPL can result in abnormal FA supply and utilization by the heart tissue that could potentially initiate and sustain cardiac dysfunction during diabetes.

We are?seeking an active?individual who can join our laboratory as a PhD Student working on the regulation of cardiac LPL in an attempt to piece together how early metabolic changes could instigate diabetic heart disease. More research information could be found on our website (http://www.pharmacy.ubc.ca/research/researchers/brian-rodrigues). We anticipate a start date of January 1, 2013. Personnel specifications of the candidate include:

??????????? A Masters degree
??????????? Interest in Biological Research
??????????? Excellent organizational ability and strong communication skills
??????????? Experience in cell isolation, cell culture, Western Blotting, rtPCR and enzymology

Interested individuals are requested to submit an application and current CV to:

Rachel Wu, Graduate Programs Manager; Faculty of Pharmaceutical Sciences; The University of British Columbia; 371E-2146 East Mall, Vancouver, BC, Canada V6T 1Z3; Tel:604-827-0188; 604-827-0188.? Email: rawu@mail.ubc.ca

Application Deadline : 31 October 2012

Download this Call as PDF

Contact Adress: Rachel Wu

Contact Email: rawu@mail.ubc.ca

Posted on 2012-10-12 18:17:17

Click here to report if you think this notice is not valid or violating copyrights. Not an Official Version. Terms Apply.

Please give reference of Scholarships-Links.com when applying for above scholarship.

Source: http://www.scholarships-links.com/viewdetail/4202/PhD-Student-Position-in-Biological-Research.html

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Mystery Craft Kit: Home and Garden Welcome - Craft Test Dummies ...

Kits seem to be really hot these days. (Or have I just been living under a rock?) Scrapbook Update did a series on Kits, PaperCrafters Corner just did a WEEK on kits?and well, I?m obviously kit-deficient. So Nicole from Home and Garden Welcome offered to send me a kit ?and despite being a little nervous (my first kit- eek!) I decided to hop on the band wagon.

Before we dive in, let?s learn a little more about HomeandGardenWelcome.com, ok?

Your Home and Garden is where you make most of your memories. Let us help you?create perfect?patio or garden?the to enjoy with your family and entertain your friends. Spend time with your kids feeding the fish in your garden pond during the day, then spend the evenings entertaining your friends around the barbecue grill.?Once those memories are made, make sure you can keep them forever. Create a?scrapbook albums?or a piece of custom made art decor?to remember those lazy afternoons and hazy summer evenings and all people who make them possible.

( I?m down with that!)

First I should mention that the Home and Garden Welcome kit was a?.MYSTERY CRAFT KIT!!! So you have to have a lot of faith that Nicole will put cool things together for you and it will be well worth your $50.00 investment. ?Here?s how they are described on the site:

These kits contain coordinated supplies to spark your imagination.? Each kit is valued over $100 MSRP and can include anything from papers, inks, ribbons, buttons, brads and other embellishments to challenge your creativity.? Once you complete your project e-mail photos to MysteryKits@homeandgardenwelcome.com for your chance to win!? Full contest details can be found on the?Mystery Kit Contest Rules Page.

As the calendar changes from August to September the temperatures begin to cool and the trees begin to change. We transition from the hot days of summer to the cooler autumn. Bring together your friends and family and celebrate the comforts of home and the joy of a rustic life.

So? SPOILER ALERT..This is what I received in my September Mystery Kit:

What I got in my kit!

Here?s what I received:

• 1 pack of Graphic 45 12X12 paper (sheet music on one side, playing cards on the other)
• 1 set of TCP Studios cling-mount stamps
• 1 Perfect Pearls Mist by Ranger
• 1 Set of Perfect Pearls by Ranger (4 Perfect Pearls Powders, 2 brushes, 1 Perfect Medium stamp pad)
• 1 Graphic 45 trim package- 2 ribbons and one lace
• 1 Puffs Embossing Powder
• 1 Set of Clear Vials from 7 Gypsies
• 1 Set of Stickers from XX

Wow. That?s a LOT of product! ?(Worth well over $50.00, too.)

Now, I?m going to take a moment to philosophize before I get started. I believe that there is very little randomness in the Universe?we get what we need when we need it?and sometimes you just have to trust. I was SO excited to get this package- it was JUST. FOR. ME. No, really, it was! As some of you know, I am a musician (lookee those papers) and I have roosters in my kitchen. Really. So I?m convinced that this kit was really just for me! Ok, now ON with it already?

The hutch in my kitchen- ROOSTERS. (Hey, my grandma had ?em, too!)

So of course, considering my fondness of roosters and their presence in my kitchen, I decided to do something about this:

See that? A boring box of tissues. That just won?t do.

So I decided to prime a paper-mache tissue box cover I had in my stash. (Like you do.) And then I painted it with some antique white Martha Stewart Craft Paint.

Priming the paper mache box with Gesso first evens out the surface and primes it, making it necessary to use only 1 coat of paint.

Then I measured the sides of the box and top, ?and cut some of that pretty Graphic 45 paper to fit just inside, leaving a little boarder all around. ?I decoupaged the paper on using Mod Podge, and then I gave it a little spritz of the Perfect Pearls Mist just to add a bit of color. You can mix the Perfect Pearls Mist right into the Mod Podge for instant antiquing!

Here you can see the color variation due to the Perfect Pearls mists.

To create the top, I cut a square of paper and decoupaged it on the same way I did the sides. (Covering the hole.) When it was dry, I used a craft knife to cut across the hole, making little tabs. Then I glued those down, like this:

The view from inside the box.

When it was dry, I stamped the laurel leaves right to the top of the box using Perfect Medium. I heat-embossed it with some black embossing powder to bring that black accent color more prominently to the top.

Top of Tissue Box

Next I added the lace trim using a hot glue gun, and then topped THAT with the text ribbon trim. I think it kind of makes it look like there is a lid.

To create the focal images, I used my Spellbinders Grand Nestabilities Book Pages die and cut 4 pieces of black cardstock. I stamped my Roosters using the Perfect Medium, then dusted the Perfect Pearls in on top.

I LOVE the way the Perfect Pearls look on the black cardstock? and I?m SO glad they were in the kit! Just what I would have wanted to use anyway!

I ended up cutting 4 pieces of cardstock and then flipped one over so that I got that fancy detail on both the top and the bottom- you can see the seam, but I?m OK with that. I adhered the images to the tissue box with a tape runner. ?I then added some of those Crystal Stickers on top as little embellishments.

Side ?A.?

Side ?B.?

So now I have a sweet and coordinated tissue box to fit into my kitchen?s decor?.see?

Bless you!

So?one last thing about the Mystery Kits- if you choose to participate, there is a CONTEST! Here are some of the deets on that:

Every month Home and Garden Welcome will have a ?Mystery Kit? available for purchase. ?? The kits will be $50 each month and will include a selection of products for you to create a one of a kind piece of art.? Each month the kit will be a little different, including a different mix of papers, inks, paints, embellishments and accessories.? You won?t know what is included in the kit until it arrives!? There will be a product description giving a small hint regarding the contents of the kit as well as any recommended tools or products necessary for the kit contents.

To participate in the Mystery Kit Contest you must purchase the?Current Month?s Kit?AND you must use ALL the items in the kit prominently in your final project.? E-mail photos of your project to mysterykitcontest@homeandgardenwelcome.com before Midnight EST the last day of the contest month.? Once all projects are received I will post them on this page for you to?vote for your favorite project..

Voting will continue for 7 days and the project with the most votes will win a free Mystery Kit Gift Certificate?redeemable for a mystery kit of their choice ? future, past or present!

As you can see, there are lots of great items to work with?.but I just wasn?t able to figure out how to use them all in the project I wanted to make. (I underlined the products I used in the list above.) So obviously I wouldn?t be able to enter the contest. But what about you? Could you stretch your creativity to the limit and use ALL the items?

So..intrigued?

I do have the hint for the October kit.

Whether October calls to mind ghouls or gourds, frightful sites or frosty mornings, jack-o-lanterns or juicy apples

this kit will help you create the perfect piece of artwork for these cool fall days.

Also, I am giving everyone a preview of ONE item in the kit.? This month the kit includes a package of Inkssentials Shrink Plastic 8?10 sheets!

The link to the September kit is here:?http://www.homeandgardenwelcome.com/September-Mystery-Kit-p/mk0912.htm

And the October kit is here:?http://www.homeandgardenwelcome.com/October-Mystery-Kit-p/mk1012.htm

I?d like to thank HomeAndGardenWelcome.com for sponsoring this post and sending me the goodies to play with. I hope you?ll be inspired to try a kit and visit their website, Pinterest, ?and Facebook Page too!

Source: http://www.crafttestdummies.com/craft-projects-2/paper-crafts-craft-projects-2/mystery-craft-kit-home-and-garden-welcome/

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Miley Cyrus on Twitter: Pray for My Pup!

Source: http://www.thehollywoodgossip.com/2012/10/miley-cyrus-asks-for/

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Camden John Lachey: First Look!

Source: http://www.thehollywoodgossip.com/2012/10/camden-john-lachey-first-look/

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Lin, young Rockets ready for challenge

Houston Rockets head coach Kevin McHale answers questions during their NBA basketball media day, Monday, Oct. 1, 2012, in Houston. (AP Photo/Houston Chronicle, Brett Coomer) MANDATORY CREDIT

Houston Rockets head coach Kevin McHale answers questions during their NBA basketball media day, Monday, Oct. 1, 2012, in Houston. (AP Photo/Houston Chronicle, Brett Coomer) MANDATORY CREDIT

Houston Rockets guard Kevin Martin poses for a portrait during their NBA basketball media day, Monday, Oct. 1, 2012, in Houston. (AP Photo/Houston Chronicle, Brett Coomer) MANDATORY CREDIT

HOUSTON (AP) ? Jeremy Lin became a Broadway sensation, a coveted free agent and a merchandising magnet in Asia, all in less than a year.

In Houston, Lin will return to a role he used to enjoy at Harvard ? team leader.

The rebuilt Rockets met with the media on Monday before heading south to begin training camp, and they'll turn to their charismatic new point guard for leadership and direction.

The 24-year-old Lin is hardly a seasoned veteran with only 25 starts in the NBA. It just seems that way after Lin soared to international stardom during a remarkable run with the New York Knicks last February. A restricted free agent, Lin signed an offer sheet with Houston, but Knicks coach Mike Woodson said New York planned to re-sign him.

The Rockets amended the offer to three years and about $25 million, with about $15 million backloaded to the final year. The Knicks backed off, and Lin returned to the team that cut him last December.

"It kind of reminds me of college," said Lin, who started 87 games in the Ivy League. "Just coming in, trying to lead, trying to work hard, trying to build a culture of playing a blue-collar brand of basketball."

One Rocket who can trump Lin in experience is shooting guard Kevin Martin, who sat out the final 24 games last season. Martin half-expected to be dealt to another team over the summer, as he watched the Rockets make a flurry of moves.

"Every day, I heard 'Rockets,' and somebody leaving, somebody coming," Martin said. "I felt like I was just standing in line, waiting to come up to the front and (somebody saying), 'It's your turn to go.' But it didn't happen."

He met with general manager Daryl Morey and coach Kevin McHale and said Monday that he's committed to helping the Rockets this season.

"I know people said I was unhappy or I wanted out," Martin said. "I'm happy to be a Rocket, and I just want to be better every year."

Chandler Parsons, a second-round draft pick in 2011 who's quickly formed a close friendship with Lin, will also share the leadership role after starting 57 games as a rookie.

But even McHale concedes the Rockets will have to rely on scrappiness and guile to stay afloat this season, with most of the nucleus of last year's team ? Kyle Lowry, Courtney Lee, Goran Dragic and Luis Scola ? gone to other teams.

"We have a lot of young guys. We have to find a rotation, we've got a lot of stuff to do," McHale said. "Our goal is to try to win as many games as it takes to put ourselves in a position to get into the playoffs. That's going to be a hell of a challenge, but that's what I told our guys. We've got to find a way to get it done."

The team was flying south to the near the Mexican border later Monday and was holding its first week of practices in Hidalgo, home of its developmental league affiliate, the Rio Grande Valley Vipers. By taking training camp on the road, McHale was hoping to get a jump-start on forging team chemistry.

"It's good for a young team," McHale said. "It's good to get away for this team, starting out. It'll be nice to kind of be in a place where we'll just work."

McHale also is eager to learn the capabilities of each player, most of them virtually untested as the NBA level. Donatas Motiejunas, a 7-foot forward from Lithuania, averaged 16 points and 6.6 rebounds in Europe last year, and first-round picks Jeremy Lamb, Terrence Jones and Royce White begin their first training camps after playing for Houston's summer-league team.

"We just have so many unknowns, so many guys who haven't played with each other yet," McHale said. "It's hard to project what they're going to do. But I would be shocked if we don't play really hard and get after it."

The Rockets have been trying for years to land a cornerstone superstar, and Morey spent most of his offseason trying to acquire Dwight Howard, who signed with the Lakers. Without a top-tier player, Houston may take its lumps this season.

At least for now, Parsons thinks everyone is prepared for that.

"We know who we are," Parsons said. "We know our talent level, we know the talent level of the NBA, so we know we're going to have to do all the little things most teams don't want to do. We're going to have to go out there and take charges, and outwork everybody.

"We don't care about the expectations," he said. "We're cool with flying under the radar."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-10-02-BKN-Rockets-Media-Day/id-2d2eee2462ff45d48841f52218f91559

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John Lennon drawings coming to NYC gallery

NEW YORK (AP) ? Fans can see another artistic side of John Lennon in New York City this week.

An exhibition will feature 100 drawings and sketches by the late Beatle. It's called "The Artwork of John Lennon."

The show runs Friday through Oct. 9 at 130 Prince St. in SoHo.

It marks what would have been Lennon's 72nd birthday.

The works cover the years 1964 to 1980, the year Lennon was fatally shot outside his Manhattan apartment building.

The exhibition is being presented by his widow, Yoko Ono, as well as Bag One Arts and Legacy Productions.

A $2 donation is suggested, and the funds will benefit Citymeals-on-Wheels.

Lennon's art consists of quick sketches and the Oriental technique of sumi ink drawings.

Source: http://news.yahoo.com/john-lennon-drawings-coming-nyc-gallery-145915663.html

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Statement from HHS Secretary Kathleen Sebelius on Breast Cancer ...

FOR IMMEDIATE RELEASE October 1, 2012

Contact: HHS Press Office (202) 690-6343

Statement from HHS Secretary Kathleen Sebelius on Breast Cancer Awareness Month

In October, during National Breast Cancer Awareness Month, we remember those who have lost their lives to breast cancer, and those who are battling it now, by recommitting ourselves to their fight and spreading the word of the importance of prevention and early detection.

Despite significant advances in treatment and prevention, breast cancer remains the second leading cause of cancer death for women in the United States. However, because of the Affordable Care Act, it?s a new day for women?s health and the fight against breast cancer.

We know that the chance of successful treatment is highest when breast cancer is detected early. While not a perfect tool, mammogram screenings are key to early detection. But budgets are tight, and even moderate copays can deter many women from getting those important screenings.

Because of the Affordable Care Act ? the health care law signed by President Obama two years ago ? many private health plans and Medicare now cover mammograms and certain other preventive services with no copays or other out-of-pocket costs. This means that women can get the potentially life-saving services they need to detect breast cancer before it spreads, without worrying how a copay would affect their family budget. Last year, more than 6 million women with Medicare got a free mammogram.

Under the health care law, other services to help prevent breast cancer are also covered, such as a well-woman visit ? at no additional cost? so women have the opportunity to talk to their doctor about their health care needs, their personal risk for breast cancer, and their best options to reduce their risk. The Affordable Care Act gives women, not insurance companies or the government, control over their health care.

Women also have new rights and protections under the law against insurance company abuse. If diagnosed with breast cancer or another illness, women cannot have their coverage taken away when they need it the most simply because of a mistake made on paperwork. And beginning in 2014, it will be illegal for insurers to discriminate against anyone with a pre-existing condition, such as breast cancer.

The health reform law is also helping women who are going through costly breast cancer treatment by preventing insurance companies from imposing lifetime dollar caps on coverage. This means that women fighting breast cancer can focus on their health, their families, and living their lives, and not worrying that their insurance will run out while they still need treatment.

We have made substantial progress in reducing the burden and toll of breast cancer on American women and their families. Initiatives under the Affordable Care Act, along with ongoing research, are making real differences in the lives of American women and their families.

###

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Note: All HHS press releases, fact sheets and other press materials are available at http://www.hhs.gov/news.

You can follow HHS on Twitter @HHSgov and sign up for HHS Email Updates.

Last revised: October 1, 2012

Source: http://www.hhs.gov/news/press/2012pres/10/20121001a.html

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How Big Companies Should Innovate - Maxwell Wessel - Harvard ...

Mature corporations are designed to execute on the science of delivery ? not engage in the art of discovery. They're bad at innovation by design: All the pressures and processes that drive them toward a profitable, efficient operation tend to get in the way of developing the innovations that can actually transform the business.

This was the core thesis of the first article in this series. However, I also pointed out a paradox: being bad at innovation and good at execution isn't necessarily undesirable. Once businesses refine their model as start-ups and move towards mature operations, we as shareholders want them to shift from exploration to efficiency. We want our leaders to push their businesses toward profit generation.

But giving up the pursuit of innovation seems less than satisfying, if not unrealistic. Executives will always look for ways to achieve meaningful growth and engage in strategic renewal. If the odds were 99:1 against breakthrough innovation inside the mature company, we'd still see leaders chasing after that golden ring.

So how do you empower your corporate innovators to bring their ideas to market? How do you avoid wasting millions, if not billions, on projects destined for failure? How do you leverage your unique position to create meaningful returns and capture potential growth?

The answers to these questions aren't simple. If you're willing to acknowledge the barriers in your way, there are a few tried and true levers you can pull to ensure your intrapreneurial endeavors are better positioned for success.

Create autonomy. This is one of the most important weapons in the arsenal of new businesses. If the antibodies already exist within your organization to destroy new endeavors, you need to go outside of the organization to overcome them. In his seminal work, The Innovator's Dilemma, Clayton Christensen made the point that for disruptive innovations to be pursued effectively, they require autonomous business units. He was completely right. What's more, his solution applies not just in the case of disruptive innovation, but also the business model innovations that we repeatedly fail to embrace. The constant need to drive towards operational efficiency can be avoided through the creation of new organizations.

If Gerber's failed adult food business had been born outside of its existing organization, would the managers have distributed a product that looked like Gerber baby food? If they'd been able to pay the same amount for different packaging on the open market, what would the outcome have been? Would Gerber own today's V8? Would they operate smoothie stores like Jamba Juice? Would they have growth rates similar to Innocent, Naked and Odwalla?

We can't know for sure. But one thing is certain: faced at the onset with internal pressure to drive cost out of production, it was far less likely that Gerber could truly innovate. It could not build an adult food business within its existing structure.

Incentivize for long-term viability. Pursuing innovation inside a big company is a balancing act. The obvious assumption behind all corporate innovation is that companies have assets that can be unleashed to create value. However, in the process of unleashing this potential, leaders must make sure their innovators develop sustainability. Though giving away free support and access to infrastructure is vital in this process, doing too much of this can backfire. Leaders must manage internal transfer pricing to ensure the development of viable business models.

Imagine you want a group inside your company to figure out new ways to sell your excess widgets. To encourage this activity, you give a bunch of your excess widgets to a team and ask that they market them as something new and different. Your team comes up with a model that's wildly successful; their excess widgets sell like hotcakes. Then, when your team goes to scale up their business, you realize that they hadn't considered the cost of buying new widgets at market rates. After all, they'd been given all their widgets for free. The business then becomes unprofitable and goes belly up.

This might seem like a far-fetched example, but this type of failure happens more often than you'd think. Free access to salespeople, manufacturing capacity and marketing dollars all can inhibit the generation of sustainable business models. Transfer pricing inside a company is already a complex issue. But when it comes to innovation, it must be approached even more thoughtfully.

Test to learn. Over the past few years, Eric Ries' lean start-up movement has gained meaningful traction in the entrepreneurial community. The lean start-up puts forth an ideology of systematically testing your business model against the assumptions you're making. If you can move from uncertainty to certainty using the fewest dollars and in the shortest period of time, you're destined for great things.

The foundation of this theory, and others like it, is the scientific method. Questions are asked: Can our new asset offer a solution for our customers? Can it be profitable? Intrapreneurs must then be encouraged to test early and test often. Little by little, they can turn a hypothesis about the market into proven results.

If evidence come back that invalidates the basic hypotheses of the project, teams can cut their losses before they're too great. Simultaneously, as intrapreneurs test their ideas to gain supporting evidence for their products and services, they can justify requesting funds.

Boston Mayor Thomas Menino has been quite successful using lean operations in his efforts to innovate. A group inside his office, New Urban Mechanics, is charged with coming up with different technological solutions to city problems. Their major constraint, as described to me by one of its members, is capital. The New Urban Mechanics will only, initially, pursue opportunities that can be tackled with a small team and lean software development. By keeping the initial cost of exploration low, the office avoids stakeholder and voter scrutiny. The corporate antibodies, arguably stronger in government than anywhere else, that would normally attack innovation don't even know change is on its way. And when change does come, it works and is affordable.

Use your brain. Alfred Sloan, the late CEO of General Motors, was known for his focus on maximizing return on investment (ROI). It contributed to his success in transforming GM, a distant second in the automotive market, to a giant within the American industry.

Despite the famed CEO's respect for ROI, Sloan periodically invested in innovative efforts that couldn't possibly be justified by the numbers alone. Sloan created a central R&D unit to develop platform technologies for GM, protected the decentralized operations of his brands, and invested heavily during World War II on the hypothesis that capacity needs would pick up. When strict adherence to ROI didn't make sense, Sloan used the most valuable tool in his management portfolio ? himself.

Creating guidelines to protect innovation can work; after all, the first three steps in this post suggest as much. But at the end of the day, intuition will always play a role in management. Vision can be invaluable in forecasting where profits will flow if the world changes. So when common sense and your Excel spreadsheets don't line up, use your brain.

This is the second post in a three-part series. Read the first post here.

Source: http://blogs.hbr.org/cs/2012/10/how_big_companies_should_innovate.html

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